• S Uchino, R Bellomo, D Goldsmith, P Davenport, L Cole, I Baldwin, S Panagiotopoulos, and P Tipping.
• Department of Intensive Care and Department of Medicine, Austin & Repatriation Medical Centre, Heidelberg, Melbourne, Victoria 3084, Australia.
• Intensive Care Med. 2002 May 1; 28 (5): 651-5.

ObjectiveTo test whether hemofiltration using a hemofilter with large pores (super high flux hemofiltration) achieves effective cytokine removal.Design: Ex vivo study.SettingLaboratory of an intensive care unit in a tertiary hospital.Patients And ParticipantsFive healthy volunteers.InterventionsBlood was spiked with 1 mg of endotoxin and then circulated through a closed hemofiltration circuit with a large pore polyamide super high flux hemofilter (nominal cut-off point: 100 kDa). Hemofiltration was conducted at 1 l/h or 6 l/h of ultrafiltrate flow. Samples were taken from the arterial, venous and ultrafiltration sampling ports.Measurements And ResultsSieving coefficients (SC) above 0.6 were achieved for interleukin (IL)-1beta, IL-6 and IL-10 and SCs above 0.3 were achieved for IL-8 and TNF-alpha at 1 l/h. SCs of all cytokines (except IL-1) were reduced when the ultrafiltration rate was increased from 1 l/h to 6 l/h ( p<0.01), but cytokine clearances still increased ( p<0.01). The highest SC for albumin was 0.1 at 1 l/h and fell to 0.01 at 6 l/h. No adsorption of cytokines and albumin was observed.ConclusionHigh volume ultrafiltration using a super high flux filter achieved cytokine clearances comparable to, or greater than, those currently achieved for urea during standard continuous renal replacement therapy.

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