• Nancy G Berman and Robert A Parker.
• Department of Pediatrics, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA, USA. berman@gcrc.rei.edu
• Bmc Med Res Methodol. 2002 Aug 9; 2: 10.

BackgroundMeta-analysis is often considered to be a simple way to summarize the existing literature. In this paper we describe how a meta-analysis resembles a conventional study, requiring a written protocol with design elements that parallel those of a record review.MethodsThe paper provides a structure for creating a meta-analysis protocol. Some guidelines for measurement of the quality of papers are given. A brief overview of statistical considerations is included. Four papers are reviewed as examples. The examples generally followed the guidelines we specify in reporting the studies and results, but in some of the papers there was insufficient information on the meta-analysis process.ConclusionsMeta-analysis can be a very useful method to summarize data across many studies, but it requires careful thought, planning and implementation.

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