• Neuroscience letters · Jun 2011

    Review

    Human clinical trails in antiepileptogenesis.

    • Ram Mani, John Pollard, and Marc A Dichter.
    • Department of Neurology, University of Pennsylvania, United States.
    • Neurosci. Lett. 2011 Jun 27; 497 (3): 251-6.

    AbstractBlocking the development of epilepsy (epileptogenesis) is a fundamental research area with the potential to provide large benefits to patients by avoiding the medical and social consequences that occur with epilepsy and lifelong therapy. Human clinical trials attempting to prevent epilepsy (antiepileptogenesis) have been few and universally unsuccessful to date. In this article, we review data about possible pathophysiological mechanisms underlying epileptogenesis, discuss potential interventions, and summarize prior antiepileptogenesis trials. Elements of ideal trials designs for successful antiepileptogenic intervention are suggested.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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