• BMJ case reports · Jan 2014

    Case Reports

    Iatrogenic takotsubo cardiomyopathy induced by locally applied epinephrine and cocaine.

    • Jens Sundbøll, Manan Pareek, Morten Høgsbro, and Esben Hjorth Madsen.
    • Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus N, Denmark.
    • BMJ Case Rep. 2014 Jan 1; 2014.

    AbstractA 67-year-old man underwent surgery under general anaesthesia to obtain a biopsy from a tumour in the left maxillary sinus. Before the procedure a mucosal detumescence containing epinephrine and cocaine was applied onto the nasal mucosa. Shortly after termination of anaesthesia the patient developed tachycardia and an abrupt rise in blood pressure followed by a drop to critical levels. The patient turned pale and clammy but denied chest pain at any time. An ECG showed inferolateral ST-segment elevation, and troponin T was elevated at 0.773 ng/mL. An acute coronary angiography demonstrated normal coronary arteries; however, left ventriculography showed apical ballooning of the left ventricle, and the diagnosis of takotsubo cardiomyopathy was made. This was confirmed by a subsequent transthoracic echocardiography. Four days later the patient had complete resolution of the symptoms, and a new echocardiography showed normalisation of the left ventricular systolic function with no signs of apical ballooning.

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