• Kevin M Terrell, Anthony J Perkins, Paul R Dexter, Siu L Hui, Christopher M Callahan, and Douglas K Miller.
• Department of Emergency Medicine, Indiana University, Indianapolis, Indiana, USA. kterrell@regenstrief.org
• J Am Geriatr Soc. 2009 Aug 1; 57 (8): 1388-94.

ObjectivesTo evaluate the effectiveness of computer-assisted decision support in reducing potentially inappropriate prescribing to older adults.DesignRandomized, controlled trial.SettingAn academic emergency department (ED) in Indianapolis, Indiana, where computerized physician order entry was used to write all medication prescriptions.ParticipantsSixty-three emergency physicians were randomized to the intervention (32 physicians) or control (31 physicians) group.InterventionDecision support that advised against use of nine potentially inappropriate medications and recommended safer substitute therapies.MeasurementsThe primary outcome was the proportion of ED visits by seniors that resulted in one or more prescriptions for an inappropriate medication. The main secondary outcomes were the proportions of medications prescribed that were inappropriate and intervention physicians' reasons for rejecting the decision support.ResultsThe average age of the patients was 74, two-thirds were female, and just over half were African American. Decision support was provided 114 times to intervention physicians, who accepted 49 (43%) of the recommendations. Intervention physicians prescribed one or more inappropriate medications during 2.6% of ED visits by seniors, compared with 3.9% of visits managed by control physicians (P=.02; odds ratio=0.55, 95% confidence interval=0.34-0.89). The proportion of all prescribed medications that were inappropriate significantly decreased from 5.4% to 3.4%. The most common reason for rejecting decision support was that the patient had no prior problems with the medication.ConclusionComputerized physician order entry with decision support significantly reduced prescribing of potentially inappropriate medications for seniors. This approach might be used in other efforts to improve ED care.Trial RegistrationClinical trials.gov Identifier: NCT00297869.

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