• Ge Yu, Rong Wan, Guojian Yin, Jie Xiong, Yanling Hu, Miao Xing, Xiaofeng Cang, Yuting Fan, Wenqin Xiao, Lei Qiu, Xingpeng Wang, and Guoyong Hu.
• Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine 301 Yanchang Road, Zhabei District, Shanghai 200072, People's Republic of China.
• Int J Clin Exp Patho. 2014 Jan 1; 7 (5): 2133-42.

AbstractDiosmetin (3', 5, 7-trihydroxy-4'-methoxyflavone), the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit, was considered to exhibit anti-inflammatory and antioxidant properties. Our study aimed to investigate the effect of diosmetin in a murine model of cerulein-induced acute pancreatitis (AP). Experimental AP was induced in mice by seven intraperitoneal injection of cerulein (50 ug/kg) at hourly intervals. Diosmetin (100 mg/kg) or vehicle was pretreated 2 h before the first cerulein injection. After 6 h, 9 h, 12 h of the first cerulein injection, the severity of acute pancreatitis was evaluated biochemically and morphologically. Pretreatment with diosmetin significantly reduced serum levels of amylase and lipase; the histological injury; the secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6; myeloperoxidase (MPO) activity, trypsinogen activation peptide (TAP) level, the expression of inducible nitric oxide synthase (iNOS); and the nuclear factor (NF)-κB activation in cerulein-induced AP. This study showed that administration of diosmetin demonstrated a beneficial effect on the course of cerulein-induced AP in mice. Therefore, diosmetin may become a new therapeutic agent in future clinical trials for treatment of AP.

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