• Jie Li, Jose Ollague Sierra, Linjian Zhu, Ling Tang, Kirah Rahill, Bassim El-Sabawi, Wen Liu-Mares, Patricia M Mertz, and Stephen C Davis.
• Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
• Exp. Dermatol. 2013 Oct 1; 22 (10): 674-6.

AbstractA porcine deep partial-thickness wound model was used to evaluate the effects of a newly developed topical aqueous oxygen emulsion (TOE) on wound repair. The wounds were treated with TOE, which contains super-saturated oxygen or vehicle control. Semiquantitative immunofluorescent staining was performed to examine protein production for type I and type III collagen and vascular endothelial growth factor (VEGF). Immunofluorescent staining revealed higher protein levels of type I and type III collagen and VEGF in the TOE treatment group. Histological analysis also revealed improved angiogenesis and granulation tissue formation with topical TOE treatment and was consistent with the protein expression. In addition, the histology examination demonstrated faster epithelialization in wounds treated with TOE. The study suggests that sustained high levels of oxygen released by TOE may promote the process of wound repair through increasing collagen deposition and angiogenesis as well as stimulating epithelialization.© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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