• Int. J. Antimicrob. Agents · May 2015

    Subtleties in practical application of prolonged infusion of β-lactam antibiotics.

    • Jan J De Waele, Jeffrey Lipman, Mieke Carlier, and Jason A Roberts.
    • Department of Critical Care Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Electronic address: Jan.DeWaele@UGent.be.
    • Int. J. Antimicrob. Agents. 2015 May 1; 45 (5): 461-3.

    AbstractProlonged infusion (PI) of β-lactam antibiotics is increasingly used in order to optimise antibiotic exposure in critically ill patients. Physicians are often not aware of a number of subtleties that may jeopardise the treatment. In this clinically based paper, we stress pragmatic issues, such as the importance of a loading dose before PI, and discuss a number of important practicalities that are mandatory to benefit from the pharmacokinetic advantages of prolonged β-lactam antibiotic administration.Copyright © 2015 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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