• Ji-Hyun Lee, Eun-Kyung Yoo, In-Kyung Song, Jin-Tae Kim, and Hee-Soo Kim.
• From the Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.
• Eur J Anaesthesiol. 2015 May 1;32(5):330-5.

BackgroundWe investigated the effects of concomitant administration of sevoflurane and ramosetron on the QT interval, the interval between the peak and end of the T wave (Tpe) and Tpe/QT ratio in children.ObjectivesTo compare the effects of concomitant administration of ramosetron and sevoflurane on heart rate corrected interval with Bazett's formula (QTc), Tpe interval and Tpe/QT ratio.DesignA prospective observational study.SettingElective orthopaedic surgery with patient-controlled analgesia.PatientsForty children aged between 3 and 12 years.InterventionECG recordings were collected before induction (BASE), before sevoflurane administration (SEVO) and after the administration of ramosetron (SEVO and R).Main Outcome MeasuresThe heart rate corrected interval with Bazett's formula (QTc), Tpe interval and Tpe/QT ratio were calculated and the changes were analysed using repeated-measures analysis of variance (ANOVA).ResultsThe QTc interval at BASE was 388.5 ± 29.3 ms. It increased with sevoflurane anaesthesia to 414.9 ± 21.4 ms and did not change with the administration of ramosetron (418.2 ± 23.0 ms). The Tpe interval and Tpe/QT ratio did not differ between measurements. No ventricular arrhythmias occurred during the study.ConclusionRamosetron was not associated with prolongation of the QTc interval when it was given concomitantly with sevoflurane in children. No ventricular arrhythmias or other adverse effects occurred during the study.

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