• M L Cheatham, L D Nelson, M C Chang, and K Safcsak.
• Department of Surgical Education, Orlando Regional Medical Center, FL 32806, USA. mikec@orhs.org
• Crit. Care Med. 1998 Nov 1; 26 (11): 1801-6.

ObjectiveTo evaluate the clinical utility of right ventricular end-diastolic volume index (RVEDVI) and pulmonary artery occlusion pressure (PAOP) as measures of preload status in patients with acute respiratory failure receiving treatment with positive end-expiratory pressure.DesignProspective, cohort study.SettingSurgical intensive care unit in a Level I trauma center/university hospital.PatientsSixty-four critically ill surgical patients with acute respiratory failure.InterventionsAll patients were treated for acute respiratory failure with titrated levels of positive end-expiratory pressure (PEEP) with the goal of increasing arterial oxygen saturation to > or =0.92, reducing FIO2 to <0.5, and reducing intrapulmonary shunt to < or =0.2. Serial determinations of RVEDVI, PAOP, and cardiac index (CI) were recorded.Measurements And Main ResultsTwo hundred-fifty sets of hemodynamic variables were measured in 64 patients. The level of PEEP ranged from 5 to 50 cm H2O (mean 12+/-9 [SD] cm H2O). At all levels of PEEP, CI correlated significantly better with RVEDVI than with PAOP. At levels of PEEP > or =15 cm H2O, CI was inversely correlated with PAOP, but remained positively correlated with RVEDVI.ConclusionsCI correlates significantly better with RVEDVI than PAOP at all levels of PEEP up to 50 cm H2O. RVEDVI is a more reliable predictor of volume depletion and preload recruitable increases in CI, especially in patients receiving higher levels of PEEP where PAOP is difficult to interpret.

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