• K Shimizu, H Ogura, T Asahara, K Nomoto, M Morotomi, Y Nakahori, A Osuka, S Yamano, M Goto, A Matsushima, O Tasaki, Y Kuwagata, and H Sugimoto.
• Department of Clinical Quality Management, Osaka University Hospital, Suita-City, Osaka, Japan. kshimizu@hp-cqm.med.osaka-u.ac.jp
• Neurogastroenterol. Motil. 2011 Apr 1; 23 (4): 330-5, e157.

BackgroundThe gut is an important target organ for injury after severe insult, and resolution of feeding intolerance is crucial for critically ill patients. We investigated gut flora and motility to evaluate the impact of gastrointestinal dysmotility on septic complications in patients with severe systemic inflammatory response syndrome (SIRS).MethodsSixty-three ICU patients with severe SIRS were divided into two groups depending on their intestinal condition. Patients with feeding intolerance comprised patients who had feeding intolerance, defined as ≥ 300 mL reflux from nasal gastric feeding tube in 24 h, and patients without feeding intolerance comprised patients with no feeding intolerance. We compared fecal microflora, incidences of bacteremia, and mortality between these groups.Key ResultsAnalysis of feces showed that patients with feeding intolerance had significantly lower numbers of total obligate anaerobes including Bacteroidaceae and Bifidobacterium, higher numbers of Staphylococcus, lower concentrations of acetic acid and propionic acid, and higher concentrations of succinic acid and lactic acid than those in patients without feeding intolerance (P ≤ 0.05). Patients with feeding intolerance had higher incidences of bacteremia (86%vs 18%) and mortality (64%vs 20%) than did patients without feeding intolerance (P ≤ 0.05).Conclusions & InferencesGut flora and organic acids were significantly altered in patients with severe SIRS complicated by gastrointestinal dysmotility, which was associated with higher septic mortality in SIRS patients.© 2010 Blackwell Publishing Ltd.

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