• Int. Arch. Allergy Immunol. · Jan 2012

    Inflammatory markers and acid-base equilibrium in exhaled breath condensate of stable and unstable asthma patients.

    • Maria Magdalena Tomasiak-Lozowska, Ziemowit Zietkowski, Katarzyna Przeslaw, Marian Tomasiak, Roman Skiepko, and Anna Bodzenta-Lukaszyk.
    • Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland. maria.lozowska@umwb.edu.pl
    • Int. Arch. Allergy Immunol. 2012 Jan 1; 159 (2): 121-9.

    BackgroundNitrosative and acid stress play an important role in the pathogenesis of asthma. The aim of this study was to evaluate whether, in asthmatics, a link exists between the concentrations of nitrite/nitrate, ammonia and pH values in exhaled breath condensate (EBC) and asthma severity, lung function, exhaled nitric oxide (F(ENO)), total IgE, eosinophil cationic protein (ECP) and blood eosinophilia.MethodsThe above-mentioned parameters were measured in 19 healthy volunteers and 91 allergic asthmatics divided into three groups, i.e. 22 subjects with steroid-naïve stable asthma, 35 with inhaled corticosteroid (ICS)-treated stable asthma and 34 with ICS-treated unstable asthma.ResultsCompared with healthy subjects, EBC from asthmatics had significantly lower pH values and ammonia concentrations and significantly higher levels of nitrite/nitrate. The extent of these changes was higher in patients with unstable than in patients with steroid-naïve and stable ICS-treated asthma. The EBC pH was positively correlated with ammonia and negatively correlated with nitrite/nitrate, F(ENO) or blood eosinophilia in all three groups of asthmatics. Significant positive correlations between EBC nitrite/nitrate and blood eosinophilia, ECP levels or F(ENO) were observed in all groups of asthmatics. Significant negative correlations between EBC ammonia and nitrite/nitrate, F(ENO), ECP concentrations or blood eosinophilia were demonstrated in the groups of ICS-naïve and ICS-treated stable asthmatics.ConclusionsIn asthmatic patients there is a relationship between EBC pH, ammonia and nitrite/nitrate concentrations and other recognized markers of airway inflammation. EBC pH values, ammonia and nitrite/nitrate levels measured together may help to assess airway inflammatory status and asthma severity.Copyright © 2012 S. Karger AG, Basel.

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