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The Journal of pathology · Jan 2014
ReviewPathology is a necessary and informative tool in oncology clinical trials.
- Iris D Nagtegaal, Nicholas P West, J Han J M van Krieken, and Phil Quirke.
- Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
- J. Pathol. 2014 Jan 1; 232 (2): 185-9.
AbstractClinical trials are essential for the improvement of cancer care. The complexity of modern cancer care and research require careful design, for which input from all disciplines is necessary. Pathologists should play a key role in the design and execution of modern cancer trials, with special attention to the eligibility, stratification and evaluation of response to therapy. In the current review all these aspects are discussed, with examples from colorectal cancer trials. We describe critical issues in biomarker evaluation and development and emphasize the importance of the role of the pathologist in quality control of cancer treatment.Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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