• Kyobu Geka · Dec 2013

    [Can local administration of tranexamic acid reduce aspirin-induced bleeding in off-pump coronary artery bypass grafting( CABG) ?].

    • Masakazu Aoki, Yoshihiro Goto, Shinji Ogawa, Hiroshi Baba, and Yasuhide Okawa.
    • Department of Cardiovascular Surgery, Toyohashi Heart Center, Toyohashi, Japan.
    • Kyobu Geka. 2013 Dec 1; 66 (13): 1119-25.

    ObjectivesWe examined the effect of local administration of tranexamic acid( TA) on reducing aspirin-induced bleeding in off-pump coronary artery bypass grafting(CABG).MethodsFrom July 2009 to January 2011, 88 cases with off-pump CABG were divided into 4 groups:group C including 19 cases without preoperative aspirin or local administration of TA, group A including 23 cases with preoperative aspirin alone, group T including 19 cases with local administration of TA alone, and group AT including 27 cases with both preoperative aspirin and local administration of TA.ResultsThe bleeding volume after 24 hours in group A was significantly larger than that in group C(p=0.0085). The bleeding volume in group AT was significantly smaller than that in group A (p<0.0001), and the bleeding volume in group T was also significantly smaller than that in group C (p=0.0054). There was no significant difference between group T and AT.ConclusionsThe use of local administration of tranexamic acid indicated the reduction of postoperative bleeding even in patients with preoperative aspirin use.

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