• Lytt I Gardner, Thomas P Giordano, Gary Marks, Tracey E Wilson, Jason A Craw, Mari-Lynn Drainoni, Jeanne C Keruly, Allan E Rodriguez, Faye Malitz, Richard D Moore, Lucy A Bradley-Springer, Susan Holman, Charles E Rose, Sonali Girde, Meg Sullivan, Lisa R Metsch, Michael Saag, Michael J Mugavero, and Retention in Care Study Group.
• Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
• Clin. Infect. Dis. 2014 Sep 1; 59 (5): 725-34.

BackgroundThe aim of the study was to determine whether enhanced personal contact with human immunodeficiency virus (HIV)-infected patients across time improves retention in care compared with existing standard of care (SOC) practices, and whether brief skills training improves retention beyond enhanced contact.MethodsThe study, conducted at 6 HIV clinics in the United States, included 1838 patients with a recent history of inconsistent clinic attendance, and new patients. Each clinic randomized participants to 1 of 3 arms and continued to provide SOC practices to all enrollees: enhanced contact with interventionist (EC) (brief face-to-face meeting upon returning for care visit, interim visit call, appointment reminder calls, missed visit call); EC + skills (organization, problem solving, and communication skills); or SOC only. The intervention was delivered by project staff for 12 months following randomization. The outcomes during that 12-month period were (1) percentage of participants attending at least 1 primary care visit in 3 consecutive 4-month intervals (visit constancy), and (2) proportion of kept/scheduled primary care visits (visit adherence).ResultsLog-binomial risk ratios comparing intervention arms against the SOC arm demonstrated better outcomes in both the EC and EC + skills arms (visit constancy: risk ratio [RR], 1.22 [95% confidence interval {CI}, 1.09-1.36] and 1.22 [95% CI, 1.09-1.36], respectively; visit adherence: RR, 1.08 [95% CI, 1.05-1.11] and 1.06 [95% CI, 1.02-1.09], respectively; all Ps < .01). Intervention effects were observed in numerous patient subgroups, although they were lower in patients reporting unmet needs or illicit drug use.ConclusionsEnhanced contact with patients improved retention in HIV primary care compared with existing SOC practices. A brief patient skill-building component did not improve retention further. Additional intervention elements may be needed for patients reporting illicit drug use or who have unmet needs.Clinical Trials RegistrationCDCHRSA9272007.Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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