• P D Reiter, R Makhlouf, and A D Stiles.
• Department of Pharmacy, University Hospital, School of Pharmacy, Denver, CO 80262, USA.
• Pharmacotherapy. 1998 Jan 1; 18 (1): 63-8.

Study ObjectiveTo compare the renal, hemodynamic, and pulmonary effects of a 6-hour infusion of furosemide versus conventional bolus administration in premature infants.DesignProspective, blinded, placebo-controlled, randomized study.SettingTwo level III, university-based neonatal intensive care units.PatientsThirty premature infants with significant lung disease, requiring furosemide after a red cell infusion.InterventionsInfants received furosemide 1 mg/kg over 2 minutes, followed by a 6-hour placebo infusion, or a small loading dose of 0.1 mg/kg, followed by a slow infusion of 0.9 mg/kg over 6 hours. Serum and urine were collected to determine percentage fractional excretion of sodium (FENa).Measurements And Main ResultsUrine output and blood pressure were measured every 2 hours after furosemide administration. Percentage FENa was measured immediately before furosemide and compared with pooled urine from an 8-hour collection after furosemide administration. Serum sodium, creatinine, and calcium were measured before and 24 hours after drug administration. Mean airway pressure and percentage inspired oxygen were compared before, 1-4 hours after, and 4-12 hours after drug administration. No significant differences were detected between the two methods of drug administration.ConclusionOur data suggest that a 6-hour infusion of furosemide does not offer substantial clinical advantage over conventional bolus administration in premature infants when focusing on urine output, blood pressure, FENa, or pulmonary effect.

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