• Shigehiko Uchino, Louise Cole, Hiroshi Morimatsu, Donna Goldsmith, and Rinaldo Bellomo.
• Department of Intensive Care and Medicine, University of Melbourne, and Austin & Repatriation Medical Centre Melbourne, Heidelberg, Victoria, Australia.
• Intensive Care Med. 2002 Nov 1; 28 (11): 1664-7.

ObjectiveTo measure the sieving coefficient (SC) and clearance of vancomycin during high-volume haemofiltration (HVHF) and to evaluate the impact of different pre-dilution regimens on these variables.Design And SettingProspective interventional study in the intensive care unit in a tertiary university hospital.PatientsSeven patients with septic shock and multi-organ dysfunction.InterventionsHVHF (6 l/h fluid exchange) was performed in septic shock patients using variable proportions of their replacement fluid in pre- and post-dilution mode.Measurements And ResultsPre-filter, post-filter and ultrafiltrate vancomycin concentrations were measured simultaneously, and SC and clearance calculated. The measurements were repeated following each change in the proportion of pre-dilution fluid. SC steadily decreased as the proportion of pre-dilution decreased, changing from 0.76 in pure pre-dilution to 0.57 in pure post-dilution (p=0.0004). Clearance, however, increased with decreasing pre-dilution fluid rate, from 53.9 ml/min at pure pre-dilution to 67.2 ml/min at 2 l/h pre-dilution with 4 l/h post-dilution.ConclusionsHVHF achieves high vancomycin clearances, which despite some deterioration in SC increase with the proportion of replacement fluid given post-filter. Clinicians applying HVHF need to be aware of such clearances to avoid inadequate vancomycin dosing and to adjust therapy according to variations in HVHF technique.

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