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Thrombosis research · Apr 1988
Comparative StudyDegradation of Glu- and Lys-plasminogen by elastase in the presence or absence of tranexamic acid.
- A Takada, Y Sugawara, and Y Takada.
- Department of Physiology, Hamamatsu University, School of Medicine, Shizuoka-ken, Japan.
- Thromb. Res. 1988 Apr 15; 50 (2): 285-94.
AbstractGlu-plasminogen (Glu-plg) was degraded by elastase in the presence or absence of tranexamic acid. Glu-plg was degraded faster in the presence of tranexamic acid. Increase in the concentration of tranexamic acid resulted in increase in the appearance of degradation products, reaching a plateau level at 1 mM of tranexamic acid. Fifty percent increase in the concentration of one of degradation products was obtained at 0.22 mM of tranexamic acid, which is similar to a dissociation constant (Kd) of low affinity lysine binding sites (LBS) with tranexamic acid. As to the degradation rate of two isozymes of Glu-plg (Glu-plg I and II), Glu-plg II containing one carbohydrate chain was degraded faster than Glu-plg I containing two carbohydrate chains. Comparison of the degradation rates of Glu-plg and Lys-plg indicated that Lys-plg was degraded faster.
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