• Ann. Thorac. Surg. · Jan 2003

    Case Reports

    Favorable outcome with bivalirudin anticoagulation during cardiopulmonary bypass.

    • Zev Davis, Richard Anderson, Daniel Short, David Garber, and Araldo Valgiusti.
    • Edward Hospital, Naperville, Illinois, USA. zdavis@openheart.net
    • Ann. Thorac. Surg. 2003 Jan 1; 75 (1): 264-5.

    AbstractAn 81-year-old man with previous syncopal episodes, progressive shortness of breath, pulmonary edema, severe calcific aortic stenosis, and a history of heparin-induced thrombocytopenia required aortic valve replacement. Bivalirudin, a thrombin-specific anticoagulant, was used in place of heparin. The patient received a 50 mg bivalirudin bolus followed by an infusion between 1.5 mg x kg(-1) x h(-1) and 1.75 mg x kg(-1) x h(-1). Adequate anticoagulation was readily obtained resulting in an uneventful cardiopulmonary bypass. Activated clotting time (ACT) values steadily declined after discontinuation of the bivalirudin infusion. Bivalirudin is a practical alternative to heparin during cardiac surgical procedures.

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