• Acta Neurochir. Suppl. · Jan 1997

    Clinical Trial

    Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock.

    • M J Bell, P M Kochanek, L A Doughty, J A Carcillo, P D Adelson, R S Clark, M J Whalen, and S T DeKosky.
    • Safar Center for Resuscitation Research, University of Pittsburgh, PA, USA.
    • Acta Neurochir. Suppl. 1997 Jan 1; 70: 96-7.

    AbstractInflammation may play an important role in the evolution of damage after traumatic brain injury (TBI). IL-6 and IL-10 are markers of inflammation that are pro- and anti-inflammatory in nature, respectively. They have been used as an index of the degree of inflammation in diseases including sepsis and meningitis. We hypothesized that both IL-6 and IL-10 would be increased in the cerebrospinal fluid (CSF) of children after TBI. We measured ventricular CSF concentrations of these metabolites (ELISA) each of the first 3 days after TBI in 15 children. CSF IL-6 was increased on day 1 (p < 0.05 vs days 2 or 3). CSF IL-10 was similarly increased on day 1 (p < 0.05). CSF IL-6 after TBI is similar to serum IL-6 levels previously reported in children with septic shock. In contrast, the CSF IL-10 response was markedly attenuated following TBI compared to sepsis. These data suggest a unique balance between pro- and anti-inflammatory cytokines in brain after TBI.

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