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J Burn Care Rehabil · Jul 1993
Clinical TrialEffect of triglycyl-lysine-vasopressin on skin blood flow and blood loss during wound excision in patients with burns.
- W L Garner, P D Thomson, N P Moore, J L Rodriguez, and D J Smith.
- Department of Surgery, University of Michigan School of Medicine, Ann Arbor.
- J Burn Care Rehabil. 1993 Jul 1; 14 (4): 458-60.
AbstractExcisional therapy often results in large-volume blood loss. Triglycyl-lysine-vasopressin selectively decreases dermal blood flow and therefore was tested for efficacy in limiting intraoperative blood loss in a series of patients undergoing excisional therapy. Ten patients with symmetric injuries were treated with intravenous triglycyl-lysine-vasopressin after excision of half of their burn wound. Blood loss, which was quantified by weighing sponges used to absorb shed blood, was significantly decreased after treatment. Triglycyl-lysine-vasopressin treatment was safe and effective and should be considered in cases when large-volume blood loss is expected.
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