• Antimicrob. Agents Chemother. · Jun 1995

    Interleukin 10 reduces mortality from severe peritonitis in mice.

    • T Kato, A Murata, H Ishida, H Toda, N Tanaka, H Hayashida, M Monden, and N Matsuura.
    • Department of Surgery II, Osaka University Medical School, Japan.
    • Antimicrob. Agents Chemother. 1995 Jun 1; 39 (6): 1336-40.

    AbstractInterleukin 10 (IL-10) is known to suppress the induction of proinflammatory cytokines such as tumor necrosis factor (TNF) and IL-1 and is itself induced by monocytes and macrophages during sepsis. We studied the therapeutic efficacy of IL-10 by testing its effect on the survival rate in the murine cecal ligation-and-puncture (CLP) model. Administration of 1 microgram or more of recombinant murine IL-10 6 h after induction of sepsis decreased lethality in septic mice significantly and also suppressed the elevation of circulating TNF after sepsis. However, treatment with the same dose of IL-10 simultaneously or 6 h before induction of CLP had no effect on survival, and treatment with anti-TNF antibody after induction of CLP had no effect on the survival rate. These data suggest that cytokine modulation with IL-10 is a potential candidate for the treatment of sepsis and sepsis-related multiple organ failure.

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