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Blood Coagul. Fibrinolysis · Mar 2012
Case ReportsSuccessful management of hereditary angioedema during tonsillectomy: a case report.
- Cedric Hermans, Sébastien Vander Vorst, and Catherine Lambert.
- Hemostasis and Thrombosis Unit, Division of Adult Hematology, Belgium. cedric.hermans@uclouvain.be
- Blood Coagul. Fibrinolysis. 2012 Mar 1; 23 (2): 155-7.
AbstractHereditary angioedema (HAE) is a rare genetic disorder causing a deficiency in C1 esterase inhibitor (C1-INH) that is manifested through unpredictable oedema. We describe a case of a patient with HAE who had previously been refused surgery for tonsillitis due to the potential for oedema, in whom regular monitoring of C1-INH levels combined with intensified therapy with danazol, tranexamic acid and C1-INH concentrate enabled an uncomplicated procedure with no oedema crisis. However, clinicians should be alerted that higher overall dosages of C1-INH concentrate for perioperative prophylaxis may be required than those typically used to treat acute HAE attacks.
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