• Toru Aoyama, Takaki Yoshikawa, Tsutomu Hayashi, Shinichi Hasegawa, Kazuhito Tsuchida, Takanobu Yamada, Haruhiko Cho, Takashi Ogata, Hirohito Fujikawa, Norio Yukawa, Takashi Oshima, Yasushi Rino, and Munetaka Masuda.
• Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
• Ann. Surg. Oncol. 2014 Jun 1; 21 (6): 1983-90.

BackgroundLaparoscopy-assisted distal gastrectomy (LADG) for gastric cancer may prevent the development of an impaired nutritional status due to reduced surgical stress compared with open distal gastrectomy (ODG).MethodsThis study was performed as an exploratory analysis of a phase III trial comparing LADG and ODG for stage I gastric cancer during the period between May and December of 2011. All patients received the same perioperative care via fast-track surgery. The level of surgical stress was evaluated based on the white blood cell count and the interleukin-6 (IL-6) level. The nutritional status was measured according to the total body weight, amount of lean body mass, lymphocyte count, and prealbumin level.ResultsTwenty-six patients were randomized to receive ODG (13 patients) or LADG (13 patients). The baseline characteristics and surgical outcomes were similar between the two groups. The median IL-6 level increased from 0.8 to 36.3 pg/dl in the ODG group and from 1.5 to 53.3 pg/dl in the LADG group. The median amount of lean body mass decreased from 48.3 to 46.8 kg in the ODG group and from 46.6 to 46.0 kg in the LADG group. There are no significant differences between two groups.ConclusionsThe level of surgical stress and the nutritional status were found to be similar between the ODG and LADG groups in a randomized comparison using the same perioperative care of fast-track surgery.

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