• Leukemia research · May 2013

    Review

    Considerations for early switch to nilotinib or dasatinib in patients with chronic myeloid leukemia with inadequate response to first-line imatinib.

    • Alfonso Quintás-Cardama and Elias J Jabbour.
    • University of Texas, M.D. Anderson Cancer Center, Houston, TX, United States. aquintas@mdanderson.org
    • Leuk. Res. 2013 May 1; 37 (5): 487-95.

    AbstractClinical evidence in chronic myeloid leukemia demonstrates a significant link between optimal response to tyrosine kinase inhibitor (TKI) therapy and favorable clinical outcome. For patients with suboptimal response to first-line TKI, clinical data show that a considerable proportion can be rescued by second-line TKI. Practice guidelines now recommend that clinicians consider a switch in TKI for patients with suboptimal response as early as 3 months after first-line TKI initiation, thus allowing clinicians to intervene in a timely manner and consider the potential benefit of a switch in TKI therapy.Copyright © 2013 Elsevier Ltd. All rights reserved.

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