• Craig A E Mosley, Doris Dyson, and Dale A Smith.
• Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada NIG 2W1.
• J. Am. Vet. Med. Assoc. 2003 Jun 1; 222 (11): 1559-64.

ObjectiveTo determine minimum alveolar concentration (MAC) of isoflurane in green iguanas and effects of butorphanol on MAC.DesignProspective randomized trial.Animals10 healthy mature iguanas.Procedurein each iguana, MAC was measured 3 times: twice after induction of anesthesia with isoflurane and once after induction of anesthesia with isoflurane and IM administration of butorphanol (1 mg/kg [0.45 mg/lb]). A blood sample was collected from the tail vein for blood-gas analysis at the beginning and end of the anesthetic period. The MAC was determined with a standard bracketing technique; an electrical current was used as the supramaximal stimulus. Animals were artificially ventilated with a ventilator set to deliver a tidal volume of 30 mL/kg (14 mL/lb) at a rate of 4 breaths/min.ResultsMean +/- SD MAC values during the 3 trials (2 without and 1 with butorphanol) were 2.0 +/- 0.6, 2.1 +/- 0.6, and 1.7 +/- 0.7%, respectively, which were not significantly different from each other. Heart rate and end-tidal partial pressure of CO2 were also not significantly different among the 3 trials. Mean +/- SD heart rate was 48 +/- 10 beats/min; mean end-tidal partial pressure of CO2 was 22 +/- 10 mm Hg. There were no significant differences in blood-gas values for samples obtained at the beginning versus the end of the anesthetic period.Conclusions And Clinical RelevanceResults suggest that the MAC of isoflurane in green iguanas is 2.1% and that butorphanol does not have any significant isoflurane-sparing effects.

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