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Neurol. Med. Chir. (Tokyo) · Jan 2010
Case ReportsDirect relief of levodopa-induced dyskinesia by stimulation in the area above the subthalamic nucleus in a patient with Parkinson's disease--case report.
- Yasumasa Nishikawa, Kazutaka Kobayashi, Hideki Oshima, Chikashi Fukaya, Takamitu Yamamoto, Yoichi Katayama, Akira Ogawa, and Kuniaki Ogasawara.
- Department of Neurosurgery, Iwate Medical University School of Medicine, Morioka, Iwate, Japan.
- Neurol. Med. Chir. (Tokyo). 2010 Jan 1; 50 (3): 257-9.
AbstractA 71-year-old woman with a 25-year history of levodopa (LD)-responsive Parkinson's disease (PD) developed on-off motor fluctuation and severe peak dose dyskinesia. She underwent deep brain stimulation of the subthalamic nucleus (STN-DBS). STN-DBS induced attenuation of her cardinal PD symptoms and marked improvement of dyskinesia without reduction of LD dosage perioperatively. STN-DBS thus markedly attenuated the cardinal symptoms of PD. LD-induced dyskinesia can also be controlled via reduction of LD dosage as an indirect effect of STN-DBS. The present case provides evidence of the direct antidyskinetic effect of STN-DBS, and suggests that LD-induced dyskinesia can be inhibited by stimulation in the area above the STN.
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