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Case Reports
Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis.
- J W C Alffenaar, R van Altena, H J Bökkerink, G J Luijckx, D van Soolingen, R E Aarnoutse, and T S van der Werf.
- Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands. j.w.c.alffenaar@apoth.umcg.nl
- Clin. Infect. Dis. 2009 Oct 1; 49 (7): 1080-2.
AbstractMoxifloxacin cerebrospinal fluid (CSF) penetration was evaluated by obtaining full plasma and CSF time concentration curves for 4 patients with tuberculous meningitis. The geometric mean ratio of the areas under the curve for CSF to plasma were 0.82 (range, 0.70-0.94) at 400 mg once per day and 0.71 (0.58-0.84) at 800 mg once per day.
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