• Resuscitation · Jul 2007

    Review Meta Analysis

    Should a benzodiazepine antagonist be used in unconscious patients presenting to the emergency department?

    • Adeline Su-Yin Ngo, Charles Rabind Anthony, Miny Samuel, Evelyn Wong, and R Ponampalam.
    • Department of Emergency Medicine, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. adelinengosy@hotmail.com
    • Resuscitation. 2007 Jul 1; 74 (1): 27-37.

    UnlabelledPatients in coma with suspected drug poisoning are commonly encountered in the emergency department. Benzodiazepines are one of the most commonly used drugs in self-poisoning. Flumazenil, a benzodiazepine antagonist has been suggested as a diagnostic and treatment tool in suspected poisoning of unclear cause, but caution is required due to potential side effects. No systemic review of this literature has been done on this topic.ObjectivesThe aim of this study is to examine if flumazenil should be used in patients with coma from suspected drug poisoning.Search StrategyRandomised controlled trials were identified from the Cochrane Library, Pubmed and EMBASE. Bibliographies from included studies, known reviews and texts were searched. Content experts were contacted.Selection CriteriaRandomised controlled trials were eligible for inclusion. Studies were included if patients who presented with altered mental state from suspected drug poisoning were treated with intravenous flumazenil as compared to placebo.Data Collection And AnalysisData were extracted and methodological quality was assessed independently by two reviewers.Main ResultsSeven randomised controlled trials were included. A total of 466 patients were involved. Flumazenil was found to reverse coma from suspected drug poisoning with a relative benefit of 4.45 (95% CI 2.65, 7.45). In terms of major side effects, there was no statistical difference between flumazenil and placebo (RR 2.86, 95% CI 0.12-69.32). However, in terms of minor side effects, flumazenil was associated with a higher incidence of anxiety (RR 2.84, 95% CI 1.28-6.30) and other side effects (RR 3.73, 95% CI 2.078-6.73). There was no difference in the incidence of vomiting (RR 4.28, 95% CI 0.95-19.35).ConclusionCurrent evidence shows that flumazenil may be effective in the reversal of coma in patients presenting to the emergency department with coma from suspected drug poisoning.

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