• Tulin Akarsu Ayazoğlu, Erdal Polat, Cihan Bolat, Necdet F Yasar, Ugur Duman, Sabiye Akbulut, and Sinan Yol.
• Department of Anesthesiology and Reanimation, Kartal Kosuyolu High Specialty Training and Research Hospital, Istanbul, Turkey.
• Rev Med Chil. 2013 Apr 1; 141 (4): 477-85.

BackgroundThe ideal sedative agent for endoscopic procedures should allow a rapid modification of the sedation level and should not have any adverse effects.AimTo evaluate and compare the efficacy, safety, cost and patient satisfaction of some propofol-based sedation regimens administered during colonoscopy.Material And MethodsOne hundred twenty one patients scheduled for elective outpatient colonoscopy with conscious sedation were randomized to four groups to evaluate the administration of dexmedetomidine, sufentanil, meperidine and midazolam in combination with propofol to maintain sedation during the procedure. Evaluated outcomes were efficacy, safety, cost and patient satisfaction of sedation procedures.ResultsPatients receiving dexmedetomidine achieved a higher degree of sedation when compared with the other groups (p < 0.05). The lapse to recover protective reflexes and motor function, was significantly shorter in groups receiving dexmedetomidine or sufentanil than in groups receiving meperidine or midazolam (p < 0.05). There were no differences between groups in pre-sedation and post-sedation neurophysiologic performance, measured by the Trail Making A and B tests.ConclusionsSedation for endoscopy can be safely and effectively accomplished with low doses of propofol combined with dexmedetomidine, intranasal sufentanil, IV meperidine and IV meperidine with midazolam.

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