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Case Reports
[Brown urine : Myoglobin-induced renal failure after concomitant administration of simvastatin and amiodarone].
- U Pietsch, C Müller-Höcker, and M Filipovic.
- Klinik für Anästhesie Intensive und Rettungsmedizin, Kantonsspital St. Gallen, Rorschacherstr., 9007, St. Gallen, Schweiz. urs.pietsch@kssg.ch.
- Anaesthesist. 2016 May 1; 65 (5): 366-8.
AbstractRhabdomyolysis is a rare but well-known complication of statin therapy. The risk is considerably increased when concomitant drugs are administered that inhibit metabolism and breakdown via the cytochrome CYP3A4. We report a case of myoglobin-induced acute renal failure secondary to the concomitant use of simvastatin and amiodarone. The risk of rhabdomyolysis is mainly determined by the statin dose; in the case of the concomitant use of CYP3A4 inhibitors, a maximal daily dose of 20 mg is recommended to avoid harmful drug interactions.
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