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Revista médica de Chile · Nov 2012
Case Reports[Spontaneous activity of cutaneous nociceptors in patients with painful polyneuropathy. Report of three patients].
- Mario Campero and Sebastián Campero.
- Facultad de Medicina, Alemana-Universidad del Desarrollo, Chile. mcampero@med.uchile.cl
- Rev Med Chil. 2012 Nov 1; 140 (11): 1383-90.
AbstractPainful polyneuropathy may result from selective impairment of small diameter nerve fibers, while tactile and motor functions are preserved. In these patients clinical and electrophysiological assessment is usually unrevealing. We report three patients with a pure painful polyneuropathy. One of them had neurogenic pruritus additionally. Quantitative sensory analysis disclosed a slight warm hypoesthesia (3/3) and paradoxical hot sensation (2/3) in the feet. Intraneural recordings from the peroneal nerve demonstrated abnormal spontaneous activity in 8 of 17 nociceptive afferents. One of them displayed double firing reflecting impulse multiplication. These results support the notion that patients with pain or pruritus with a distal distribution similar to a polyneuropathy, could have small diameter afferent fiber damage, despite normal function of large diameter fibers.
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