• Marloes Faut, Kees Bisschop, Mathilde Jalving, Lukas B Been, Walter Noordzij, Frans T Peters, Annija H van der Leest, Barbara L van Leeuwen, and Geke A Hospers.
• *Department of Surgery, Division of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands †Department of Internal Medicine, Division of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. ‡Department of Nuclear Medicine & Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands §Department of Gastroenterology & Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands ¶Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Ann. Surg. 2017 Aug 22.

ObjectiveThe aim of the present study was to describe different presentations, diagnostic tools, and available treatments for melanoma metastasized to the intestines.BackgroundThe intestine is a frequent site of metastases in melanoma patients. In the current era, with long-term survival after systemic treatment, there is a need for a timely diagnosis and optimal treatment of intestinal metastases.MethodsPatients diagnosed between 2011 and 2015 with intestinal metastases of melanoma were included. Diagnostic procedures, treatment strategies, and their outcome were analyzed for all patients.ResultsA total of 22 patients were included. Twenty patients received systemic therapy for widely disseminated disease. Fourteen of these twenty patients received local treatment for symptomatic intestinal metastases. Median overall survival after detection of intestinal metastasis in patients receiving systemic treatment was 22 months. On the basis of this cohort, a treatment algorithm for treatment of patients with symptomatic intestinal melanoma metastases was constructed.ConclusionsThe treatment of intestinal melanoma metastases has changed due to the introduction of novel systemic treatments that can result in long-term survival of patients with widely metastatic melanoma. Surgeons and other clinicians should be aware of these changes in clinical practice as well as the diverse presentation of intestinal melanoma metastases and the diagnostic and therapeutic dilemmas involved.

6 keywords...

hide…