• Shannon M Bailey, Uduak S Udoh, and Martin E Young.
• Division of Molecular and Cellular PathologyDepartment of PathologyDivision of Cardiovascular DiseasesDepartment of Medicine, University of Alabama at Birmingham, 703 19th Street South, ZRB 308, Birmingham, Alabama 35294, USA.
• J. Endocrinol. 2014 Aug 1; 222 (2): R75-96.

AbstractIn association with sleep-wake and fasting-feeding cycles, organisms experience dramatic oscillations in energetic demands and nutrient supply. It is therefore not surprising that various metabolic parameters, ranging from the activity status of molecular energy sensors to circulating nutrient levels, oscillate in time-of-day-dependent manners. It has become increasingly clear that rhythms in metabolic processes are not simply in response to daily environmental/behavioral influences, but are driven in part by cell autonomous circadian clocks. By synchronizing the cell with its environment, clocks modulate a host of metabolic processes in a temporally appropriate manner. The purpose of this article is to review current understanding of the interplay between circadian clocks and metabolism, in addition to the pathophysiologic consequences of disruption of this molecular mechanism, in terms of cardiometabolic disease development.© 2014 Society for Endocrinology.

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