• Thrombosis research · Apr 2010

    Review

    Antimetastatic activities of heparins and modified heparins. Experimental evidence.

    • Lubor Borsig.
    • Institute of Physiology, University of Zürich and Zürich Center for Integrative Human Physiology, Zürich, Switzerland. lborsig@access.uzh.ch
    • Thromb. Res. 2010 Apr 1; 125 Suppl 2: S66-71.

    AbstractHeparin is commonly used for prevention or treatment of cancer-associated thromboembolism. Recent clinical evidence indicates that heparin, and low-molecular weight heparin improves survival of cancer patients. Experimental evidence from various animal models consistently supports the ability of heparin to attenuate metastasis. Heparin, apart from its anticoagulant activity contains a variety of biological activities possibly affecting cancer progression, including: inhibition of heparanase, blocking of P- and L-selectin mediated cell adhesion, and inhibition of angiogenesis. The delineation of antimetastatic activity of heparin is in the focus of several ongoing investigations. This review summarizes the current experimental evidence on the biology of heparin as a potential treatment cancer progression.

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