• Am. J. Obstet. Gynecol. · Nov 1989

    Case Reports

    Antagonism of antihypertensive drug therapy in pregnancy by indomethacin?

    • A Schoenfeld, S Freedman, M Hod, and Y Ovadia.
    • Department of Obstetric and Gynecology, Beilins on Medical Center, Tel Aviv University Medical School, Petah Tikva, Israel.
    • Am. J. Obstet. Gynecol. 1989 Nov 1; 161 (5): 1204-5.

    AbstractTwo women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions. The interaction of nonsteroidal antiinflammatory agents and beta-blockers and their role in the control of blood pressure in obstetrics are discussed. Indomethacin should not be given to pregnant patients with hypertension treated with beta-blockers.

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