• A Bueno-Cavanillas, M Delgado-Rodríguez, A López-Luque, S Schaffino-Cano, and R Gálvez-Vargas.
• Department of Preventive Medicine, University of Granada Hospital, Spain.
• Crit. Care Med. 1994 Jan 1; 22 (1): 55-60.

ObjectiveTo assess the impact of nosocomial infection on the mortality rate in an intensive care unit (ICU).DesignProspective cohort study.SettingThe ICU of the University of Granada Hospital in Spain.PatientsAll patients (n = 279) admitted for > or = 48 hrs at the ICU between December 1986 and April 1988.MeasurementsNosocomial infections were diagnosed according to Study on the Efficacy of Nosocomial Infection Control (SENIC) and Centers for Disease Control criteria. Patient severity on admission (using Acute Physiology and Chronic Health Evaluation (APACHE II) and Therapeutic Intensity Scoring Systems were also used.ResultsMortality risk was 2.48 times higher in patients with a nosocomial infection than in noninfected patients. Relative risk of mortality in nosocomially infected patients was higher in young and less severely ill patients, in those patients with respiratory diseases, and in those patients with longer ICU stays. Logistic stepwise regression analysis, adjusting for several confounding factors (affected organ system, APACHE II score, and therapeutic intensity), showed that the risk of death in nosocomially infected patients was 2.1 times greater (95% confidence interval = 1.0 to 4.41) than in patients without such infection.ConclusionsNosocomial infection increases the risk of death. The effect is stronger in younger and less severely ill patients.

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