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- Jon D Oxley, Angela M Cottrell, Susan Adams, and David Gillatt.
- Department of Cellular Pathology, Southmead Hospital, Bristol, UK. jon.oxley@nbt.nhs.uk
- Histopathology. 2009 Dec 1; 55 (6): 705-8.
AimsTo describe the histopathological features of a series of patients with ketamine-related cystitis.Methods And ResultsSeventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20.ConclusionsKetamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown.
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