• Chun-Yu Wu, Ya-Jung Cheng, Ying-Ju Liu, Tsung-Ta Wu, Chiang-Ting Chien, Kuang-Cheng Chan, and NTUH Center of Microcirculation Medical Research (NCMMR).
• From the Department of Life Science, National Taiwan Normal University (C-YW, C-TC), Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan (C-YW, Y-JC, Y-JL, T-TW, K-CC).
• Eur J Anaesthesiol. 2016 Sep 1; 33 (9): 645-52.

BackgroundPredicting whether a fluid challenge will elicit 'fluid responsiveness' in stroke volume (SV) and arterial pressure is crucial for managing hypovolaemia and hypotension. Pulse pressure variation (PPV), SV variation (SVV) and the plethysmographic variability index (PVI) have been shown to predict SV fluid responsiveness, and the PPV/SVV ratio has been shown to predict arterial pressure fluid responsiveness under various conditions. However, these variables have not been investigated in liver cirrhosis patients.ObjectiveThe objective was to evaluate SV and arterial pressure fluid responsiveness in liver cirrhosis patients by using dynamic preload and vascular tone variables.DesignA prospective study of diagnostic accuracy.SettingsA single-centre trial conducted from November 2013 to April 2015.PatientsThirty-one adult patients, recipients of a living donor liver transplantat.InterventionAn intraoperative fluid challenge with 10 ml kg of 0.9% normal saline.Main Outcome MeasuresPPV, SVV, cardiac index and systemic vascular resistance index were measured using the Pulse index Continuous cardiac system. The PVI and perfusion index were measured using the Masimo Radical 7 co-oximeter. The PPV, SVV and PVI were measured to investigate SV fluid responsiveness, and the PPV/SVV ratio, perfusion index and systemic vascular resistance index were measured to investigate arterial pressure fluid responsiveness.ResultsThe areas under the receiver operating characteristic curves for PPV, SVV and PVI were 0.794, 0.754 and 0.800, respectively (all P < 0.001). The cut-off values for PPV, SVV and PVI were 10% (sensitivity 78.3%, specificity 79.5%), 12% (sensitivity 69.6%, specificity 71.8%) and 11% (sensitivity 95.7%, specificity 59.0%), respectively. However, all investigated vascular tone variables failed to predict arterial pressure and fluid responsiveness.ConclusionDynamic preload variables predicted SV fluid responsiveness. Therefore, these variables can be used for fluid management in liver cirrhosis patients receiving mechanical ventilation. In contrast, vascular tone variables did not predict arterial pressure fluid responsiveness in liver cirrhosis patients.Trial RegistrationClinicaltrials.gov identifier: NCT01971333.

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