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- G Bryan Young.
- Departments of Clinical Neurological Sciences and Medicine, The University of Western Ontario, London, Ontario, Canada. bryan.young@lhsc.on.ca
- Crit Care. 2010 Jan 1; 14 (3): 159.
AbstractSepsis-associated encephalopathy (SAE) resembles metabolic encephalopathies but with a difference: there is the potential for enduring brain damage/dysfunction. The pathogenesis of SAE is likely multifactorial. However, the severity of SAE parallels the severity of the septic illness and the brain's microcirculation is probably affected in a similar manner to that of other organs. Mild cases of SAE are often completely reversible, but there is increasing evidence that severe cases have neurological sequelae. A better understanding of the mechanisms may lead to brain-sparing, protective strategies.
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