• Jenny I Shen, Maria E Montez-Rath, Colin R Lenihan, Mintu P Turakhia, Tara I Chang, and Wolfgang C Winkelmayer.
• Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, CA.
• Am. J. Kidney Dis. 2015 Oct 1; 66 (4): 677-88.

BackgroundAlthough warfarin is indicated to prevent ischemic strokes in most patients with atrial fibrillation (AF), evidence supporting its use in hemodialysis patients is limited. Our aim was to examine outcomes after warfarin therapy initiation, relative to no warfarin use, following incident AF in a large cohort of hemodialysis patients who had comprehensive prescription drug coverage through Medicare Part D.Study DesignRetrospective observational cohort study.Setting & ParticipantsPatients in the US Renal Data System undergoing maintenance hemodialysis who had AF newly diagnosed in 2007 to 2011, with Medicare Part D coverage, who had no recorded history of warfarin use.PredictorWarfarin therapy initiation, identified by a filled prescription within 30 days of the AF event.OutcomesDeath, ischemic stroke, hemorrhagic stroke, severe gastrointestinal bleeding, and composite outcomes.MeasurementsHRs estimated by applying Cox regression to an inverse probability of treatment and censoring-weighted cohort.ResultsOf 12,284 patients with newly diagnosed AF, 1,838 (15%) initiated warfarin therapy within 30 days; however, ∼70% discontinued its use within 1 year. In intention-to-treat analyses, warfarin use was marginally associated with a reduced risk of ischemic stroke (HR, 0.68; 95% CI, 0.47-0.99), but not with the other outcomes. In as-treated analyses, warfarin use was associated with reduced mortality (HR, 0.84; 95% CI, 0.73-0.97).LimitationsShort observation period, limited number of nonfatal events, limited generalizability of results to more affluent patients.ConclusionsIn hemodialysis patients with incident AF, warfarin use was marginally associated with reduced risk of ischemic stroke, and there was a signal toward reduced mortality in as-treated analyses. These results support clinical equipoise regarding the use of warfarin in hemodialysis patients and underscore the need for randomized trials to fill this evidence gap.Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

51 keywords...

hide…