• Brain research · Jan 1992

    Effects of lesions of locus coeruleus/subcoeruleus on diffuse noxious inhibitory controls in the rat.

    • D Bouhassira, Z Bing, and D Le Bars.
    • I.N.S.E.R.M. U.161, Paris, France.
    • Brain Res. 1992 Jan 31; 571 (1): 140-4.

    AbstractDiffuse noxious inhibitory controls (DNIC) acting on trigeminal convergent neurons were compared in sham-operated animals and rats with quinolinic acid induced lesions of the locus coeruleus/subcoeruleus (LC/SC). No significant differences were observed between control animals and those with ipsilateral, contralateral or bilateral lesions of the LC/SC, in respect of: (1) the general properties of the recorded units; and (2) the magnitude of the depressions of C-fiber-evoked responses of convergent neurons produced by immersing each paw in a 50 degrees C water bath (i.e. DNIC). It is concluded that the LC/SC is not involved, at least directly, in the supraspinal part of the loop which subserves DNIC in the rat.

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