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- Thomas L Jang and Anthony J Schaeffer.
- Department of Urology, Northwestern University Medical School, Tarry 11-715, 303 East Chicago Avenue, Chicago, Illinois 60611-3008, USA.
- World J Urol. 2003 Jun 1; 21 (2): 95-9.
AbstractThere is substantiating evidence to support the role of the immune system in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Inflammation of the prostate is mediated through the cytokine-induced expression of several factors such as chemokines, inducible nitric oxide synthase, and cyclooxygenase-2. The balance between the effects of proinflammatory and anti-inflammatory cytokines determines the outcome of the inflammatory process. Several proinflammatory and anti-inflammatory cytokines have been identified in CPPS patients, their roles characterized, and their inter-relationships defined. Study of this system will provide further insights into the etiology of CP/CPPS, and lead the way for the development of novel therapeutic approaches for this morbid condition.
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