• Frank Hildebrand, Hans-Christoph Pape, Martijn van Griensven, Sven Meier, Sandra Hasenkamp, Christian Krettek, and Manfred Stuhrmann.
• Trauma Department and Department of Human Genetics, Medical School Hannover, Carl-Neuberg Strasse 1, 30625 Hannover, Germany. Hildebrand.Frank@mh-hannover.de
• Shock. 2005 Dec 1; 24 (6): 518-22.

AbstractSevere trauma induces sustained changes of the immune response, which are thought to be related to secondary organ dysfunction. Despite a similar injury severity, the extent of the inflammatory response may vary between polytraumatized patients. It is unclear whether inflammatory variability is associated with genetic variations. In this prospective cohort study, patients were included when the following criteria were fulfilled: Injury Severity Score >16, age 18 to 60 years, and a survival >48 h after injury. Four different polymorphisms (TNF-Nco1, IL-1-Taq1, IL-6-174G/C, and IL-8-251A/T) were determined. Patients were separated according to the severity of the systemic inflammatory response syndrome (SIRS; ACCP/SCCM criteria: >2 criteria at 2 consecutive days or at 3 days of the observation period: group +SIRS;

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