• Int J Obstet Anesth · Feb 2015

    5-HT3 receptor antagonists do not alter spontaneous contraction of pregnant myometrium in vitro.

    • Xuemei Lin, Yu Du, Yuying Tang, Kui Zeng, Juan Ni, Jin Liu, and Jie Zhou.
    • Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China.
    • Int J Obstet Anesth. 2015 Feb 1;24(1):41-5.

    Background5-HT3 receptor antagonists are effective antiemetics for perioperative use. However, their effects on myometrial contractility remain unknown. We examined whether three different 5-HT3 receptor antagonists could affect the contraction of human myometrium.MethodsSamples of human myometrium were taken from parturients undergoing elective cesarean delivery. Effects of ondansetron, granisetron and tropisetron (over a range of 1-10(4)ng/mL) on spontaneous contraction (ratios of amplitude, interval, and duration of the contraction) were examined and compared to saline controls (n=6 for each agent).ResultsNone of the three 5-HT3 receptor antagonists significantly affected myometrial contraction.Conclusion5-HT3 receptor antagonists do not affect the contraction of myometrial strips isolated from term pregnant women.Copyright © 2014 Elsevier Ltd. All rights reserved.

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