• P Nutr Soc · Aug 2001

    Review

    The evidence for glutamine use in the critically-ill.

    • R D Griffiths.
    • Intensive Care Research Group, Department of Medicine, University of Liverpool, UK. rdg@liverpool.ac.uk
    • P Nutr Soc. 2001 Aug 1; 60 (3): 403-10.

    AbstractResearch into the metabolic role of glutamine in trauma and sepsis brings evidence to suggest a conditional deficiency occurs because increased and altered tissue demands exceed endogenous production. Such a deficiency has functional implications, and the restorative provision of parenteral glutamine has been shown to offer improved clinical outcomes in a variety of conditions. In the critically-ill it is associated with improvements in immune function, and improved survival from infection leading to an overall improved outcome.

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