• Bruce Buckingham, Darrell M Wilson, Todd Lecher, Ragnar Hanas, Kevin Kaiserman, and Fergus Cameron.
• Lucile Packard Children's Hospital at Stanford, Pediatric Endocrinology, Stanford, California, USA. buckingham@stanford.edu.
• Diabetes Care. 2008 Nov 1; 31 (11): 2110-2.

ObjectiveDespite a high incidence of nocturnal hypoglycemia documented by the use of continuous glucose monitoring (CGM), there are no reports in the literature of nocturnal hypoglycemic seizures while a patient is wearing a CGM device.Research Design And MethodsIn this article, we describe four such cases and assess the duration of nocturnal hypoglycemia before the seizure.ResultsIn the cases where patients had a nocturnal hypoglycemic seizure while wearing a CGM device, sensor hypoglycemia (<60 mg/dl) was documented on the CGM record for 2.25-4 h before seizure activity.ConclusionsEven with a subcutaneous glucose lag of 18 min when compared with blood glucose measurements, glucose sensors have time to provide clinically meaningful alarms. Current nocturnal hypoglycemic alarms need to be improved, however, since patients can sleep through the current alarm systems.

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