• Expert Opin Drug Metab Toxicol · Apr 2015

    Review Comparative Study

    Pharmacokinetic/pharmacodynamic evaluation of eslicarbazepine for the treatment of epilepsy.

    • Monika Banach, Kinga K Borowicz, and Stanisław J Czuczwar.
    • Medical University of Lublin, Department of Pathophysiology , Jaczewskiego 8, PL-20-090 Lublin , Poland +48 81 718 7365 ; +48 81 718 7364 ; czuczwarsj@yahoo.com.
    • Expert Opin Drug Metab Toxicol. 2015 Apr 1; 11 (4): 639-48.

    IntroductionEslicarbazepine acetate (ESL) is a novel antiepileptic drug registered as the adjunctive treatment of partial-onset seizures in adults. As a third-generation medication, ESL is believed to have favorable efficacy/safety profile and pharmacokinetic properties in comparison with related drugs (carbamazepine and oxcarbazepine).Areas CoveredThe aim of the paper was to evaluate pharmacodynamic and pharmacokinetic properties of ESL with aspect to epilepsy treatment. The review of the scientific literature was based on the PubMed database, Clinical Trials, FDA and European Medicines Agency websites to elicit current information on drug metabolism, mechanism of action and efficacy/safety profile.Expert OpinionResults of clinical trials indicate that ESL possessed a favorable profile of anticonvulsant efficacy and tolerability as an add-on therapy in adult patients at daily doses of 800 and 1200 mg. Pediatric trials are in progress and their results will allow to characterize a role of ESL in the treatment of epilepsy in children.

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