• Br J Clin Pract · Apr 1997

    Case Reports

    Prolongation of prothrombin time with the use of indomethacin and warfarin.

    • T Y Chan.
    • Department of Clinical Pharmacology, Prince of Wales Hospital, Shatin, Hong Kong.
    • Br J Clin Pract. 1997 Apr 1; 51 (3): 177-8.

    AbstractA patient with a greatly prolonged international normalised ratio (INR) during the combined use of warfarin and indomethacin is described. In patients on warfarin, non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided as far as possible. If NSAIDs are absolutely necessary, patients should be closely monitored for prolongation of INR and bleeding.

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