• Masui · Jul 2008

    Review

    [New developments in neuromuscular blocking agents].

    • Tetsutaro Otagiri.
    • Hokushin General Hospital, Nagano 383-8505.
    • Masui. 2008 Jul 1; 57 (7): 819-23.

    AbstractCurare was clinically used in a patient with acute appendicitis by Griffith and Johnson in January 1942. From the day on, the development of new muscle relaxants went on in the world. Since pancuronium was synthesized by Savage in 1964, it was widely used in clinical cases because it provided sufficient muscle relaxation during operation. At present, pancuronium, vecuronium and rocuronium are routinely used in the world. In the future, we expect development of new muscle relaxants with rapid onset, intermediate duration of action, rapid recovery and without side effects.

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